Isothermal Microcalorimetry in Pharmaceutical Science


This webinar will review the microcalorimetric techniques that are most commonly used within pharmaceutical science, including stability and compatibility tests, determination of small amounts of amorphic content, and characterizing polymorphism.

A microcalorimeter can quantify the amount and rate of heat release from chemical processes associated with stability and shelf life of a drug or a formulation, with processes caused by the interaction of one component with another or physical processes such as crystallization or polymorphic transformations. The data can be both qualitative and quantitative and can be used to determine the relevant characteristics of a sample.

Microcalorimetry has the advantage of being general, non-destructive, and very sensitive. The high sensitivity of the technique makes it possible to obtain reliable stability data within hours or days, and at close to ambient storage conditions. It is general in the way it can detect both chemical and physical changes within the sample, both being critical for the performance of the pharmaceutical. The non-destructive nature of the technique allows for further analysis of the sample after completion of the calorimetric measurement.

About the Speaker

Malin Suurkuusk is the Isothermal Calorimetry Product Manager / Application Specialist at TA Instruments. She holds a Masters of Science Degree in Biochemistry from Stockholm University, and a PhD from the University of Lund where she studied in the lab of Prof. Ingemar Wadsö. She has worked extensively with Differential Scanning Calorimetry and Isothermal Titration Calorimetry, as well as other biophysical methods. Her early work in microcalorimetry instrument development included responsibilities in product management, applications lab management and marketing at Thermometric in Sweden. She is considered the world’s leading expert on the TAM isothermal instruments with numerous microcalorimetry publications. In October of 2014 she was recognized for her contributions to the field of microcalorimetry, and featured as a Biophysicist in Profile by the Biophysical Society.