This webinar on “Detecting Drug-Excipient Incompatibility” is the final installment of a three-part series on the use of differential scanning calorimetry to characterize crystalline structure of foods and pharmaceuticals. The proposed approach is:
- Fast; taking just days to detect chemical interaction between an API and candidate excipient, and less than a week to explore reaction mechanism and kinetics.
- Thorough; provides the opportunity to identify reaction products using a combination of Modulated DSC and any preferred analytical technique (HPLC, MS, XRD etc.)
- Easy to Interpret; chemical interaction causes a lowering of the temperature for the endothermic peak associated with loss of crystalline structure.
“Apparent Melting” is the basis for the ability to detect chemical interaction between materials. As discussed in Part 2 of this series, apparent melting always causes a change in chemistry, the result of drug-excipient incompatibility. Parts 1 and 2 are available for viewing in the TA Instruments webinar library.
About the Speaker
Len Thomas joined the DuPont thermal analysis business in 1974 after spending 6 years as a research chemist in DuPont Photo Products. He is a Fellow in the North American Thermal Analysis Society (NATAS) and has taught many of their short courses.
Len was part of the management team that acquired the thermal business from DuPont in 1990 to create TA Instruments. Prior to becoming President of TA Instruments from 1996 to 2000, Len held positions in Sales, Sales Management, Marketing, and Applications Development. Len started his consulting business, DSC Solutions LLC, in 2005 and continues to support many TA Instruments customers.
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