Antibodies are the most rapidly growing form of therapeutic. High-throughput methods of characterization are essential as companies and researchers move to develop new candidates. In this webinar, Dr. Shawn Owen discusses advanced characterization techniques to assess antibody-drug conjugates (ADCs) and antibody-fusion proteins. For ADCs, the level of payload and site of conjugation are determined using LC/MS. For both ADCs and antibody-fusion proteins, thermal stability and binding affinity are characterized using DSC and ITC respectively. These methods can be used for the in-depth analysis of these biologics and for routine product validation.
About the Speaker
Shawn C. Owen, Ph.D.
Assistant Professor, Department of Pharmaceutics and Pharmaceutical Chemistry
Adjunct Assistant Professor, Departments of Internal Medicine, Biomedical Engineering, Medicinal Chemistry
University of Utah
Shawn C. Owen, Ph.D. is an Assistant Professor in Pharmaceutics and Pharmaceutical Chemistry and Adjunct Professor of Internal Medicine at the University of Utah. He is also a member of the Huntsman Cancer Institute Experimental Therapeutics Program and the Nano-Institute of Utah. Dr. Owen’s research focuses on evaluating the pharmaceutic stability of antibody-based therapeutics, creating ADCs that induce self-amplifying therapeutic cascades, and engineering antibody-split enzyme systems for diagnostic applications. He has published ~25 research papers on drug delivery and biotechnology, and his research has produced 4 patent applications. Dr. Owen is recognized with several prominent university teaching awards and is sought for outreach workshops by both academic and industry sponsors.
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