Elucidating Thermodynamic Details of Biologic and Small Molecule Drugs using Microcalorimetry
2020-05-27    

Overview

Researchers are working tirelessly to understand the basic chemical details of viral pathogenesis, viral protein structures, and identifying therapeutics to disrupt and prevent disease. There are different modes of therapies evolving that include small-molecule antiviral drugs, mRNA, and protein-based vaccines. Microcalorimetry is one powerful tool for the development and characterization of the mechanism of action for these therapies. Isothermal Titration Calorimetry (ITC), Nano Differential Scanning Calorimetry (nanoDSC), and Isothermal Calorimetry (IC) are label-free and immobilization free analytic methods used for critical thermodynamic measurements. The focus of this webinar will be on utilizing these techniques to study molecular binding, biomolecular thermostability, long-term stability and their use in quality control; each an essential step in the development of a successful drug/vaccine candidate.

About the Speaker

Dr. Calliste Reiling is an Application Engineer at TA Instruments, currently supporting the microcalorimetry product line. She received her Ph.D. in Pharmaceutical Sciences from University of Nebraska Medical Center, where she investigated the thermodynamic properties of a variety of DNA and RNA secondary structures, their targeting reactions with partially complementary strands and the importance of water and ions. She also received her master’s from University of Nebraska Medical Center in Biochemistry and Molecular Biology with research centered around the structural biology of regulatory proteins involved in the endocytic pathway and their binding interactions. Calliste joined TA Instruments in 2018. Her key responsibilities at TA Instruments are customer support, consultation, and teaching microcalorimetry training courses.